Frazier joined Merck in 1992, and became general counsel of the company in 2006. As general counsel, he was credited with overseeing the company’s defense against Vioxx-related litigation. From 2007 to 2010, he served as executive vice president and president of the company’s global human health unit. In 2010, he became Merck’s president and on January 1, 2011 its CEO.
On November 11, 2011, as a member of the Penn State board of trustees, the board selected Frazier as chairman of a blue ribbon commission empaneled to investigate a child sex abuse scandal involving a former assistant football coach and allegations of a cover up by university officials